Abstract
BackgroundIn Uganda, malaria vector control interventions and case management with Artemisinin Combination Therapies (ACTs) have been scaled up over the last few years as a result of increased funding. Data on parasitaemia prevalence among children less than 5 years old and coverage of interventions was collected during the first two Malaria Indicator Surveys (MIS) conducted in 2009 and 2014, respectively. In this study, we quantify the effects of control interventions on parasitaemia risk changes between the two MIS in a spatio-temporal analysis.MethodsBayesian geostatistical and temporal models were fitted on the MIS data of 2009 and 2014. The models took into account geographical misalignment in the locations of the two surveys and adjusted for climatic changes and socio-economic differentials. Parasitaemia risk was predicted over a 2 × 2 km2 grid and the number of infected children less than 5 years old was estimated. Geostatistical variable selection was applied to identify the most important ITN coverage indicators. A spatially varying coefficient model was used to estimate intervention effects at sub-national level.ResultsThe coverage of Insecticide Treated Nets (ITNs) and ACTs more than doubled at country and sub-national levels during the period 2009–2014. The coverage of Indoor Residual Spraying (IRS) remained static at all levels. ITNs, IRS, and ACTs were associated with a reduction in parasitaemia odds of 19% (95% BCI: 18–29%), 78% (95% BCI: 67–84%), and 34% (95% BCI: 28–66%), respectively. Intervention effects varied with region. Higher socio-economic status and living in urban areas were associated with parasitaemia odds reduction of 46% (95% BCI: 0.51–0.57) and 57% (95% BCI: 0.40–0.53), respectively. The probability of parasitaemia risk decline in the country was 85% and varied from 70% in the North-East region to 100% in Kampala region. The estimated number of children infected with malaria declined from 2,480,373 in 2009 to 825,636 in 2014.ConclusionsInterventions have had a strong effect on the decline of parasitaemia risk in Uganda during 2009–2014, albeit with varying magnitude in the regions. This success should be sustained by optimizing ITN coverage to achieve universal coverage.
Highlights
In Uganda, malaria vector control interventions and case management with Artemisinin Combination Therapies (ACTs) have been scaled up over the last few years as a result of increased funding
Our study demonstrates that malaria control interventions have had a strong effect on the decline of parasitaemia risk in Uganda during 2009–2014, albeit with varying magnitude in the regions
This success should be sustained by optimizing Insecticide Treated Nets (ITNs) coverage to achieve universal coverage and by timely replacing worn-out ITNs
Summary
In Uganda, malaria vector control interventions and case management with Artemisinin Combination Therapies (ACTs) have been scaled up over the last few years as a result of increased funding. Malaria is still a leading global health problem, its burden has been on a decline in recent years [1]. This decline which started in the early 1990s prior to the global campaign of scaling up of control interventions in mid2000s continued through the post-scale-up period [2]. During the period 2000–2015, declines in global malaria incidence and deaths of up to 37 and 60%, respectively were reported [3, 6] These declines were mainly attributed to the impact of Insecticide Treated Nets (ITNs) and malaria case management with Artemisinin Combination Therapies (ACTs)
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