Abstract
This work was devoted to the analysis of the role of epigenetic mechanisms (histone acetylation, DNA methylation, histone serotonylation) in the formation, storage, and reconsolidation of long-term food aversive memory in the snail. In the first part of the work, we investigated the effect of systemic administration of sodium butyrate, an inhibitor of histone deacetylase, in a model of conditioned food aversion reflex of the snail. We have shown that the administration of sodium butyrate to animals with poor memory resulted in memory enhancement. Further, in experiments using the DNA methyltransferase blocker RG108, it was found that impaired DNA methylation impairs long-term food aversive memory in the snail. However, memory reactivation neutralizes the effect of inhibiting the activity of DNA methyltransferases. In the final section of the work, the hypothesis of the involvement of transglutaminase-mediated serotonylation in the processes of reconsolidation of food aversive memory in the snail was tested. Behavioral analysis showed that administration of the transglutaminase blocker monodansylcadaverine (hence, blockade of serotonylation) after a reminder disrupted the reconsolidation process and led to memory suppression/erasure.
Published Version
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