Abstract
ABSTRACT
 BACKGROUND. Chronic rhinosinusitis is a heterogeneous sinonasal inflammatory disease with constant symptoms and recurrent exacerbations, which affects about 10% of the world's population. Age-related changes in the nasal mucosa (involutive immunodeficiency, atrophic changes, etc.) can affect the course of the inflammatory process, which, in turn, should be borne in mind when planning therapeutic interventions.
 AIMS - to study the features of local production of IL-4, IL-6, IL-8, IL-10 in elderly and senile persons with chronic rhinosinusitis.
 MATERIALS AND METHODS. The study included patients aged 45 to 90 years with a confirmed diagnosis of "chronic rhinosinusitis" in the acute stage, who gave written informed consent to the study. The exclusion criteria were: age up to 45 years; allergic rhinitis; primary immunodeficiency; smoking; oncological disease of any organ system; chronic polypous rhinosinusitis; acute (exacerbation of chronic) diseases of other localization; vaccination; use of immunotropic drugs for 3 months before the start of the study. The scope of the laboratory examination included determination of the concentration of cytokines IL-4, IL-6, IL-8, IL-10 in nasal secretions by enzyme immunoassay.
 RESULTS. The analysis of the determined values showed that the maximum level of IL-4 was determined in younger persons with rhonic rhinosinusitis 45-59 years old compared with older persons. In our study, the maximum content of IL-6 occurred in a group of patients aged 75-90 years, while the cytokine level significantly exceeded IL-6 in a group of healthy age-related patients, which indicates a more pronounced inflammatory reaction in patients of the oldest group with chronic rhinosinusitis. Cytokine levels above 600 pg/ml were found mainly in patients with chronic rhinosinusitis. Patients of group 4 had high IL-10 values and their values went beyond the range of the comparison groups.
 CONCLUSION. The maximum level of macrophage-monocytic cytokines (IL-6 and IL-8) and anti-inflammatory IL-10 is determined in nasal flushing in patients with chronic rhinosinusitis aged 75-90 years, the highest detectable values of IL-4 are characteristic of patients aged 45-59 years.
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