The content of adiponectin, resistin in serum and their ratio in patients with chronic heart failure in overweight and obesity depending on severity of disease, body mass index, age, gender and myocardium contractile ability

Abstract

Recently more and more attention of researchers is paid to determining of adiponectin and resistin role in the development, progression and outcomes of chronic heart failure (CHF) with overweight and obesity, given the continuing increase in the incidence of both pathologies. Purpose – to examine the contents of adiponectin and resistin in serum and their ratio in patients with CHF in overweight and obesity depending on severity of disease, body mass index, age, gender and contractile myocardial ability. Materials and Methods. We examined 100 patients of the main group who had CHF of II–III functional class (FC) on the background of normal, overweight and obesity I–III degree. The comparison group included 12 patients with cardiac pathology and normal weight without clinical and instrumental signs of CHF, matched by age and gender. The control group consisted of 12 healthy subjects with normal weight. The presence of normal, overweight and degree of obesity was calculated based on the body mass index (BMI). The level of adiponectin and resistin in the blood serum was determined with ELISA method. Results. In patients with CHF, overweight and obesity the content of adiponectin and resistin in serum is increased and depends on FC of disease and age. Increasing degree of overweight and reducing the myocardium contractile ability are characterized by higher levels of resistin. The resistin/adiponectin ratio in patients with CHF, overweight and obesity increases with increasing BMI, in relation to the adiponectin/resistin ratio opposite changes occur. Conclusions. In CHF patients with concomitant overweight and obesity is an excessive activation of adipocytokines system, which is manifested by increase in the content of adiponectin, resistin, resistin/adiponectin ratio and a reduction of adiponectin/resistin index.