The Connection between Dopamine and Marijuana

Abstract

Known as the most commonly used illegal drug, marijuana has upheld its infamous reputation for decades. This psychoactive drug instills feelings of euphoria and energy when smoked or consumed. As its popularity increases, the perception of the harm induced by marijuana is declining. Uninformed individuals continue to smoke marijuana without considering it risky behavior. Without being aware of the risks that marijuana poses, more individuals are likely to develop addictions. Dopamine is a neurotransmitter in the brain that has many key roles for both the body and the brain. It is responsible for satisfaction, motivation, motor control, and arousal. Through examination of the molecular structure of dopamine, the molecular structure of marijuana, and dopaminergic pathways in the brain, it is evident that there is a connection between marijuana use and decreased levels of dopamine. Long-term usage of marijuana has been shown to dysregulate the mesolimbic dopaminergic pathway. The mesolimbic pathway is a branch of neurons projecting from the ventral augmented area to the ventral striatum. Major functions of this pathway include addiction, pleasure, and reward-seeking behavior. Based on these defenses, there is a reasonable conclusion that chronic marijuana use leads to lower levels of dopamine in the brain.