THE CONDITION OF THE LIPOPEROXIDATION SYSTEM IN PREMATURE NEWBORNS AFTER PERINATAL HYPOXIA

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Objective:to determine the role of the indicators of lipid peroxidation and antioxidant protection in the pathogenesis of perinatal hypoxia in premature newborns.Methods. The authors studied two groups of premature newborns: 24 infants born at 34-36 weeks of gestation (late premature children), and 7 children with gestation age of 32-34 weeks (moderately premature children). The authors assessed the levels of ceruloplasmin, total antioxidant activity and malonic dialdehyde in the blood serum.Results.Comparison of the studied indicators revealed higher levels of antioxidant protection and malonic dialdehyde in late premature newborns, which can be associated with greater activity of metabolic processes and resistance to oxidative stress in this group.The authors studiedsuch factors as the sex of the child and the degree of asphyxia at birth and their impact on the values of lipid peroxidation and antioxidant activity. They found that the male infants had a significant increase in the level of ceruloplasmin and antioxidant activity in comparison with the female infants. The children with moderate asphyxia at birth had the highest values of malonic dialdehyde and anti-oxidative protection.Conclusion.The processes of lipoperoxidation and antioxidant protection are optimally balanced in late premature infants, thus, we believe that they better adapted in conditions of hypoxia.