THE CONDITION OF THE DENTOALVEOLAR SYSTEM OF RATS AT THE BACKGROUND OF HEPATITIS AND DYSBIOSIS MODELLING

Abstract

Problem: impact of liver malfunction on the condition of hard and soft tissues of the oral cavity.Aim: to study the condition of the dentoalveolar system in rats at the background of experimental dysbiosis and toxic hepatitis.Methods. The research was carried out in 1-month old male rats. Intact animals served as the control group. Hepatitis modelling (group 2) was performed by intra-abdominal introduction of hydrazine sulphate (50 mg/kg twice a week) for 5 weeks, dysbiosis (group 3) was formed by adding lincomycin (70 mg/kg into potable water), rats from group 4 were given lincomycin at the last week of hepatitis formation to model dysbiosis. Estimation of caries process was performed by the method of A. P. Levytskyi, the activity of elastase and acid phosphatase was determined in the tissues of gums, and the activity of alanine aminotransferase, acid phosphatase and amount of cholesterol – in the serum.Main results. Experimental modelling in rats of both hydrazine hepatitis and dysbiosis resulted in the liver malfunction. Simultaneously, pathological changes in the oral cavity, namely increase of caries process intensity and growth of activity of inflammation markers (elastase and acid phosphatase) in the rats’ gums were observed. The most expressed inflammation of gums was observed when the pathologies were combined.Simultaneous modelling of dysbiosis and hepatitis was accompanied by increase in the activity of “liver” markers of inflammation (alanine aminotransferase and acid phosphatase) and increase of the amount of cholesterol in blood.Conclusions: dysbiosis enhances the liver pathology and increases the degree of inflammation in rats’ gums.