THE CONCENTRATION OF CREATINE IN HEART, DIAPHRAGM, AND SKELETAL MUSCLE IN UREMIA

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Article1 April 1942THE CONCENTRATION OF CREATINE IN HEART, DIAPHRAGM, AND SKELETAL MUSCLE IN UREMIAHARRY GROSS, M.D., MARTA SANDBERG, PH.D.HARRY GROSS, M.D.Search for more papers by this author, MARTA SANDBERG, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-4-737 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe rôle of creatine in muscle metabolism has been well established. All voluntary muscles of vertebrates are rich in creatine, whereas smooth muscle contains relatively little. Muscle efficiency stands in a definite relationship to the amount of creatine present.Numerous investigators have determined the creatine content of heart and skeletal muscle. As early as 1913 Myers and Fine1 reported on musclecreatine under normal conditions. They established the fact that urinary creatinine and muscle creatine are interdependent in a given species. Denis,2 in 1916, studied the creatine content of normal psoas muscle.Constabel,3in 1921, was the first to determine...Bibliography1. MYERSFINE VCMS: The creatine content of muscle under normal conditions. Its relation to the urinary creatinine, Jr. Biol. Chem., 1913, xiv, 9. CrossrefGoogle Scholar2. DENIS W: Creatine in human muscle, Jr. Biol. Chem., 1916, xxvi, 379. CrossrefGoogle Scholar3. CONSTABEL F: Ueber den Kreatingehalt des menschlichen Herzmuskels bei verschiedenen Krankheitszustaenden, Biochem. Ztschr., 1921, cxxii, 152. Google Scholar4. SEECOFLINEGARMYERS DPCRVC: The difference in creatine concentration of the left and right ventricular cardiac muscles, Arch. Int. Med., 1934, liii, 574. CrossrefGoogle Scholar5. LINEGARFROSTMYERS CRTTVC: Variation in creatine content of human cardiac and voluntary muscle at autopsy, Arch. Int. Med., 1938, lxi, 430. CrossrefGoogle Scholar6. COWAN DW: The creatine content of the myocardium of normal and abnormal human hearts, Am. Heart Jr., 1934, ix, 378. CrossrefGoogle Scholar7. HERRMANNDECHERDOLIVER GGT: Creatine changes in heart muscle under various clinical conditions, Am. Heart Jr., 1936, xii, 689. CrossrefGoogle Scholar8. BODANSKYPILCHER MJF: Clinical significance of the creatine reserve of the human heart, Arch. Int. Med., 1937, lix, 232. CrossrefGoogle Scholar9. CHANUTINSILVETTE AH: A study of creatine metabolism in the nephrectomized white rat, Jr. Biol. Chem., 1929-1930, lxxxv, 179. CrossrefGoogle Scholar10. BODANSKY M: Creatine in human muscle, Jr. Biol. Chem., 1931, xci, 147. CrossrefGoogle Scholar11. ROSEHELMERCHANUTIN WCOMA: Modified method for the estimation of total creatinine in small amounts of tissues, Jr. Biol. Chem., 1927, lxxv, 543. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York City*Received for publication October 7, 1940.From the Medical Division and Division of Laboratories, Montefiore Hospital for Chronic Diseases, New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUraemic ToxinsUraemic ToxinsUremic Cardiomyopathy in Hemodialysis PatientsStudies on whole blood and muscle creatine levels: Effect of systemic and local anoxia, of cardiac failure and compensation, and of alphatocopherol administrationNeurohormanal bedingte Herzkrankheiten (Pathogenese und Therapie)The heart in uremia 1 April 1942Volume 16, Issue 4Page: 737-749KeywordsAttentionCreatineCreatinineMusclesMyocardiumSkeletal musclesSmooth muscles ePublished: 1 December 2008 Issue Published: 1 April 1942 PDF downloadLoading ...