Abstract

Creatine in the form of phosphocreatine is thought to play a significant part in muscular activity, and the functional capacity of muscle is apparently reflected by its creatine content. It is of interest to determine in what degree the retention of nitrogenous products influences the level of creatine in heart muscle and how the creatine content is also influenced by clinical and morphological manifestations of cardiac incompetency. A study of the creatine content of heart muscle should therefore offer many interesting possibilities from the standpoint of both creatine metabolism and heart disease which are complementary to each other.A preliminary report of our work dealing with this subject was presented before this Society in January, 1932, the first publication appearing in April, 1934.1 The concentration of creatine in the left ventricular muscle of the human was found to exceed that of the right ventricle by about 30%. Attention was also called to certain correlations between creatine content, and ...

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