Abstract
Genetic approaches to dissecting complex traits in animal models increasingly use transcript levels as a molecular phenotype and as validation for predictions of gene function. A recent study in BMC Biology using these approaches shows the complexity of the genetic contribution to aggressive behavior in Drosophila.
Highlights
Aggressive behavior is another complex behavioral trait that can be efficiently modeled in Drosophila [3,4]
Given the observation that aggressive behavior in flies has such an apparently complex genetic basis, it is worth reviewing the motivations for using such a behavioral genetic model
It is ideal for artificial selection for a target trait and for genetic modification of candidate genes
Summary
Neuropsychiatric geneticists are focusing considerable attention on the investigation of quantitative human behavioral traits, postulating that such phenotypes could be more straightforward to genetically map than neuropsychiatric disorders. Quantitative phenotypes may be simpler than clinically heterogeneous diseases, there is still little evidence that human behavioral quantitative trait loci (QTL) will be easy to identify For this reason there is a tremendous appeal in using the powerful tools available for genetic investigation of simple model organisms; genes implicated in behavioral variation in flies or worms can be targeted for various forms of analysis in mammals, including humans. Investigations of clock mutants in Drosophila led to the discovery of the first circadian rhythm gene, period, and to cellular pathways underlying circadian behavior [1]; this line of investigation was subsequently successfully extended in rodents as well as humans [2] Aggressive behavior is another complex behavioral trait that can be efficiently modeled in Drosophila [3,4]. Perhaps circadian rhythm phenotypes will prove more an exception than the rule; when it comes to behavior, a simple system does not guarantee simple genetics
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
