The comparison of ticagrelor and clopidogrel on patients undergoing percutaneous coronary intervention with acute ST elevated myocardial infarction

Abstract

Objective To compare the effects of ticagrelor and clopidogrel on patients undergoing percutaneous coronary intervention(PCI) with acute ST elevated myocardial infarction(STEMI). Methods 120 patients with STEMI received PCI within 12h of symptom onset in our hospital were randomly divided into clopidogrel treated group(n= 60)and ticagrelor treated group(n= 60). Serum was collected before surgery and 36 hours after PCI for ALT,Cr,CK- MB, and MA. Cardiac ultrasound was examined, too. All patients were followed 6 months post- PCI for main adverse cardiovascular and cerebrovascular events(MACCE)and medicine side effect. Results No significantly difference was noted in baseline between the two groups. The level of CKMB and MA in the ticagrelor treated group[CK- MB(56.5±8.3)U/L,MA(45.9±6.4)mm[and clopidogrel treated group[CK- MB(74.3±9.6)U/L,MA(35.6±7.3)mm]were significant difference(CK- MB,P= 0.043;MA,P= 0.038). The MACCE of patients in ticagrelor treated group were significantly lower than patients in clopidogrel treated group during post- PCI 6 months follow- up(The ratio of angina in ticagrelor group was 1.7%,while in clopidogrel group was 6.7%,P= 0.042). Conclusion Ticagrelor is more effective in suppress the function of platelet, decrease MACCE in patients with STEMI undergoing PCI. Key words: Myocardial infarction; Percutaneous transluminal coronary angioplasty; Ticagrelor; Clopidogrel