Abstract
Synchronous populations of diploid cells ofChlamydomonas reinhardi were exposed to a bifunctional (Nitrogen Mustard) and a monofunctional (Diethyl Sulphate) alkylating agent at various stages of the pre-meiotic interphase and meiosis, and the effect on recombination in the arg 1/pab 2 region of linkage group I assessed. Both compounds affected recombination—the monofunctional one depressing it during two short periods, one just pre-meiosis when the main DNA duplication for meiosis is thought to occur, and the other in early prophase. The bifunctional compound on the other hand depressed recombination over an extended period. These effects have been related to the ability of the agents used to affect DNA synthesis and the different temporal patterns of response interpreted in terms of differential repair activities. The results provide additional evidence of the existence of two periods during which recombination can be affected.
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