Abstract
145 patients (67 children and 78 adolescents) from the multidrug-resistant tuberculosis infection focies took part in the complex microbiological study. The children and adolescents had undergone treatment for the pulmonary multidrugresistant tuberculosis. The study showed that MDR TB was by 1.7 times more often revealed in the adolescents as compared to the children, while the risk of MDR TB was by 3.7 times higher for the children than for the adolescents. The drug resistance profile of the children and the sources of infection almost completely coincided. The resistance to HRSE (66.1%) and HRESZ (13.6%) developed in the adolescents more often than in the children and adults. The study proves the importance of defining the drug resistance profile in the exposed children and adolescents from the multidrugresistant tuberculosis focies.
Highlights
At the time when the epidemiological situation of tuberculosis is getting worse, special attention should be paid to children from the tuberculosis infection focies
Of all children and adolescents infected with tuberculosis 45 (77.1%) of them were from the infection focies [1 – 3, 5, 7]
The study proved that the tuberculosis occurrence in the multidrug-resistant TB focies had increased by
Summary
At the time when the epidemiological situation of tuberculosis is getting worse, special attention should be paid to children from the tuberculosis infection focies. Of all children and adolescents infected with tuberculosis 45 (77.1%) of them were from the infection focies [1 – 3, 5, 7]. The wider use and advancement of the molecular and genetic testing for the multidrug resistant tuberculosis will contribute to the early detection of the multidrug resistance in children, adolescents and the sources of infection [4 − 6, 8]. Taking into account that the pulmonary multidrug-resistant tuberculosis and the extensively drug-resistant tuberculosis occurrence has significantly increased in the recent years, the study of the drug resistance profile of MBTin the exposed children and adolescents from the drug-resistant tuberculosis focies has been crucial for providing the most efficient antimycobacterial therapy and preventative care
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