Abstract
Between the genotypical potentials and given phenotypical expressions, cell behaviour is hypothesised largely depending on local distributed control mechanisms resulting from delicate mass flux balances involving biochemical (including cytokine, endocrine and paracrine factors) and mechanical signalling pathways. Better knowledge and exogenous control of these mechanisms is a major objective of our ESA programme in biotechnology through the integrated use of natural sciences and engineering sciences. The control of cell potency and differentiation and of cell regulation mechanisms (including apoptosis and migration triggering events) will have a huge impact on regenerative medicine (tissue engineering), and will also improve our understanding of phenomena important in immune diseases, the ageing process, and cancer. A summary is given of current research projects which have in common the understanding of the cell-environment relationship or the development of analytical and processing methods in the discipline of animal cell technology.
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