Abstract
Objective:A thyroid rat model combining functional and anatomical information would be of great benefit for better modeling of thyroid physiology and for absorbed dose calculations. Our aim was to show that 124I-PET and CT small animal imaging are useful as a combined model for studying thyroid physiology and dose calculation. Methods: Seven rats were subjects for multiple thyroid 124I-imaging and CT-scans. S-values [mGy/MBqs] for different thyroid sizes were simulated. A phantom with spheres was designed for validation of performances of the small animal PET and CT imaging systems. Results:Small animal image-based measurements of the activity amount and the volumes of the spheres with a priori known volumes showed a good agreement with their corresponding actual volumes. The CT scans of the rats showed thyroid volumes from 34–70 mL. Conclusions:The wide span in volumes of thyroid glands indicates the importance of using an accurate volume-measuring technique such as the small animal CT. The small animal PET system was on the other hand able to accurately estimate the activity concentration in the thyroid volumes. We conclude that the combination of the PET and CT image information is essential for quantitative thyroid imaging and accurate thyroid absorbed dose calculation.
Highlights
The aim of this work was to demonstrate the possibility and usefulness of using laboratory rats using a combination of the PET (Positron Emission Tomography) and the CT (Computed Tomography) techniques [1] as an in vivo animal model for the studies of thyroid physiology and dosimetry
An in vivo small animal model can be of great interest for a better understanding of human thyroid physiology and dosimetry
This study shows that quantitative thyroid imaging with 124I can be accurately performed with small animal PET combined with small animal CT
Summary
The aim of this work was to demonstrate the possibility and usefulness of using laboratory rats using a combination of the PET (Positron Emission Tomography) and the CT (Computed Tomography) techniques [1] as an in vivo animal model for the studies of thyroid physiology and dosimetry. Such a realistic, i.e., translational, and applicable animal model, for real animal morphology, is essential for reliable modeling of human thyroid physiology compared with rigid thyroid phantoms. The importance of small animal CT for the volume determination of the thyroid and the absorbed dose calculations was investigated
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