The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury

Abstract

Aim: This study co-evaluated the 2 quoted histologic variables after the cytokine erythropoietin (Epo) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of endosalpingeal karyorrhexis (EK) or salpingitis (S) in an induced ischemia reperfusion (IR) animal experiment. Methods: The 2 main experimental endpoints at which the EK and S scores were evaluated, were the reperfusion 60thmin (for A & C groups) and the reperfusion 120thmin (for B & D groups). Specially, the groups A and B were processed without drugs, whereas the groups C and D after Epo administration. Results: The first preliminary study showed that Epo hardly non significantly increased the EK scores by the grade “without lesions” 0.0181818 [-0.0679319 - +0.1042955] (p-value=0.6715). The other preliminary study found that Epo did not influence the S scores (p-value=1.0000). Both studies were co-estimated since they belong to the same experimental setting. This study co-evaluated the combined diagnostic values of both variables together. Conclusions: Epo again hardly non significantly increased both scores for these histologic parameters at the grade of “without lesions” 0.0090909 [-0.0339659 - +0.0521478] (p-value=0.6715) since they were co-evaluated together.