Abstract

Objective To observe the clinicopathological features of malignant fibrous histiocytoma (MFH) from non-soft tissue organs,and compare the differential expression of Ezrin and HMG-CoA reductase between MFH and non-MFH sarcoma.Methods We reviewed and analyzed the clinical and pathological records of 9 patients with diagnosed non-soft tissue derived MFH in our hospital.Immunohistochemical staining was performed for ezrin and HMG-CoA reductase in these MFH cases and other mesenchymal sarcomas,respectively.Results The 9 MFH cases presented with nonspecific symptoms and imaging manifestations.Six cases were classified as storiform-pleomorphic MFH,2 cases as inflammatory MFH,and the remaining 1 case as giant cell MFH.Expressions of Ezrin and HMG-CoA reductase were significantly stronger in MFH cases than other non-MFH sarcomas.Poor prognosis seemed to be associated with younger age.Conclusions Our study provided the potential value of Ezrin and HMG-CoA reductase as well as certain characteristics and clinicopathologic features for diagnosis and differential diagnosis of MFH from non-soft tissue organs. Key words: Histiocytoma, malignant fibrous ; Pathology, clinical ; Diagnosis ; Ezrin ; HMG-CoA reductase

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