Abstract
To explore the relationship between abnormal expression of mtp53 , p16 and Bcl-2 protein and oncogenesis and development of lung cancer. Expression of mtp53 , p16 and Bcl-2 protein was detected in 114 lung cancer tissues by immunohistochemistry , and 14 normal lung tissues as control. Over-expression of mtp53 protein was not related to pathological type and histological grade of lung cancer ( P > 0. 05) ,but correlated with lymph node status ( P < 0. 05) . Positive expression of p16 was closely related to histological grade of lung cancer and lymph node metatasis ( P < 0. 05) ,but not to pathological type ( P > 0. 05) . The positive rate of Bcl-2 protein expression in SCLC was significantly higher than that in NSCLC ( P < 0. 05) . mtp53 , p16 and Bcl-2 genes may play important roles in the oncogenesis and development of lung cancer.
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