The clinical value of the dynamic change of serum carbohydrate antigen 125 in the evaluation of the therapeutic effect and prognosis in patients with epithelial ovarian cancer

Abstract

Objective To explore the clinical value of the dynamic change of serum carbohydrate antigen 125 (CA125) in the evaluation of the therapeutic effect and prognosis in patients with epithelial ovarian cancer (EOC).Methods The clinical data of 84 patients with EOC were retrospectively analyzed.The change of before and after treatment,the half-life of CA125,the relationship between the clearance time of CA125 and the survival time and recurrence of patients were investigated.Results After operation,the serum level of CA125 was significantly lower than that before treatment(t =11.306,P ＜0.01).After 6 cycles of standard chemotherapy,the serum CA125 again decreased evidently(t =6.265,P ＜ 0.01).In the half-life of CA125 (T1/2) ≤ 20d group,the survival time was significantly longer than T1/2 ＞ 20d group(t =3.394,P ＜ 0.01).Compared with CA125 negative conversion time(NT) ＞ 8 weeks group,the survival time of NT ≤ 8 weeks was significantly longer (t =2.791,P ＜ 0.01),the recurrence rate was significantly lower(22.9％ vs.58.3％) (x2 =10.941,P ＜0.01),the recurrence time was later(t =15.965,P ＜0.01).Conclusion The dynamic change of CA125 has important clinical value in the evaluation of the therapeutic effect and prognosis of patients with EOC.EOC patients with short CA125 half-life,faster negative conversion time have better treatment effect,longer survival,lower recurrence rate after operation. Key words: Carcinoembryonic antigen; Ovarian neoplasms; Effects; Diagnosis