The clinical value of serum tumor markers in diagnosis of colorectal cancer

Abstract

Objective To investigate the clinical application value of serum tumor markers CA72-4,CA125,CA19-9 and CEA in the diagnosis of colorectal cancer.Methods 4 serum tumor markers CA72-4,CA125,CA19-9 and CEA levels in 50 cases with colorectal cancer(group A),50 cases with benign colorectal lesions(group B) and 50 healthy subjects(group C) were determined by chemiluminescence immunoassay and then analyzed statistically.Results The CA72-4,CA125,CA19-9 and CEA in group A were (18.46 ± 1.28) μg/L,(81.20 ± 5.82) tμg/L,(90.34 ± 5.39) ku/L and (28.44 ± 2.65) μg/L,which were significantly higher than those in group B (t =8.21,8.82,7.99,8.42,P ＜ 0.05) and group C (t =9.01,9.65,9.21,9.62,all P ＜ 0.05) ; while the differences between group B and group C were not significant (P ＞ 0.05).The CA72-4,CA125,CA19-9 and CEA testing positive rates were significantly lower than combined detection (x2 =7.62,9.04,7.79,6.05,all P ＜ 0.05).Conclusion Serum tumor markers CA72-4,CA125,CA19-9 and CEA in the diagnosis of colorectal cancer have important clinical significance,and the combined detection can improve the accuracy of diagnosis of colorectal cancer,which has better clinical value. Key words: Tumor markers, biological; Serologic tests ; Colorectal neoplasms