The clinical trials of Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets for the post-stroke depression

Abstract

Objective To observe the effect of Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets for the post-stroke depression (PSD). Methods The random number table method was used to divide the 150 patients with PSD into the observation group and control group, 75 cases in each group. On the basis of conventional treatment of stroke, the control group took oral flupentixol and melitracen tablets, and the treatment group add Chaihu-Longgu-Muli decoction on the basic treatment of control gorup. The treatment of two groups last 1 month. The serum APN concentration was detected before and after treatment. Besides, the HAMD, NIHSS scores, and the clinical curative effect were observed and compared. Results The total effective rate of the observation group was 81.3%, and control group was 58.7%, which the difference between the two groups showed the statistical significance (P<0.05). After treatment, the serum APN (7.8 ± 3.7 mg/L vs. 6.1 ± 3.3 mg/L, t=2.970) level in the observation group was significantly higher than that in the control group (P<0.05). The HADM (16.4 ± 3.6 vs. 19.6 ± 4.9, t=4.558), NIHSS (5.0 ± 1.6 vs. 7.7 ± 2.0, t=9.129) scores in the observation group were significantly lower than those in the control group (P<0.01). Conclusions The Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets can reduce the serum APN level of PSD patients, improve patients with depression, alleviate patients' neurologic deficits. Key words: Stroke; Depression; Chaihu-Longgu-Muli decoction; Adiponectin