The clinical study on metabolic disorders in PCOS women

Abstract

Objective To explore the characteristic of metabolic disorders between adolescent and childbearing period PCOS women with obesity or without obesity.Methods 80 PCOS patients were according to obesity divided into 52 patients with PCOS(BMI ≥25kg/m2) and 28 patients with non-obese PCOS (BMI ＜ 25kg/m2),and according to age divided into 36 cases of adolescent(age 14-19 years) and 44 cases of child-bearing age PCOS patients (age 20-32 years).The height,weight,blood pressure,oral glucose tolerance test (OGTT),insulin releasing test (IRT),serum lipid,liver function test were observed.Results (1)Compared with non-obese PCOS women,the obese PCOS women had significantly higher fasting blood insulin,HOMA-IR,fasting blood glucose,AUCG,serum lipid (TC,TG,LDL,ApoB),and the more serious impaired glucose tolerance(IGT).(2)Compared with adolescent PCOS women,the child-bearing period PCOS women had significantly higher AUCG,serum lipid,and more serious IGT.Conclusion The adolescent and child-bearing period PCOS patients always have different degree metabolic disorders.The obese PCOS women especially obese child-bearing period PCOS women may have increased risk of suffering from metabolic disorders in glucose and lipid.For adolescent PCOS women particularly obese ones,we should take early screening,diagnosis,intervention,to avoid the further development and long-term complications. Key words: Polycystic ovary syndrome; Puberty; Obesity