Abstract
Hematopoietic pre-B-cell leukemia transcription factor-interacting protein (HPIP), is known to promote tumor development and metastasis. However its role in cervical cancer remains unknown. The purpose of this study was to investigate the clinical significance of HPIP expression and the prognosis of patients with cervical cancer. Fresh frozen tissues from 10 samples of cervical cancer and 8normal cervical tissues were analyzed for HPIP expression using real-time reverse transcription PCR and Western blot analysis. A total of 129 paraffin-embedded surgical specimens from patients with CC were collected for an immunohistochemistry assay to measure HPIP expression. Correlations of HPIP expression with clinicopathological factors and prognosis of patients with cervical cancer were analyzed. The HPIP expression at both the mRNA and protein levels was significantly higher in cervical cancer tissues than in normal cervical tissues (P<0.001). HPIP overexpression was significantly associated with high FIGO stage (P=0.005), Histological grade (P<0.001), Ascular tumor embolus (P=0.004), Iinterstitial infiltration (P<0.001), Tumor size (P=0.001) and Lymph node metastasis (P=0.005). Moreover, results revealed that HPIP expression was an independently prognostic factor for both overall survival [hazard ratio (HR): 8.874; 95% CI: 1.186–66.393; P=0.033] and disease-free survival [(HR): 11.523; 95% CI: 1.531–86.746; P=0.018] in patients with cervical cancer. The present study provides evidence that HPIP predicts metastasis and poor survival, highlighting its potential function as a therapeutic target for cervical cancer.
Highlights
Cervical cancer comprises almost 12% of all female cancers, making it the fourth most common cancer among women worldwide
Hematopoietic pre-B-cell leukemia transcription factor-interacting protein (HPIP) expression was low in normal tissues, whereas high expression was found in tissues from patients with cervical cancer (P
To the best of our knowledge, the present study is the first to assess the status of HPIP expression at both the mRNA and protein levels as well as the first to assess the association of clinicopathological parameters and prognostic significance of HPIP protein expression in CC
Summary
Cervical cancer comprises almost 12% of all female cancers, making it the fourth most common cancer among women worldwide. 80% of cervical cancer cases occur in developing countries, and approximately 70% are identified as an advanced disease [1]. A recent study suggests that 61,691 patients were newly diagnosed with CC in China in 2012, accounting for 12% of the new CC cases worldwide [2]. The identification of novel cancer biomarkers that can predict the treatment response and prognosis of CC is urgently needed. Our previous studies demonstrated that HPIP overexpression is an independent predictor of chemotherapy resistance and epithelial ovarian carcinoma prognosis [5, 6]. The expression of HPIP as a www.impactjournals.com/oncotarget predictive biomarker for clinical significance has not been investigated in patients with cervical cancer
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