The Clinical Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Treatments in 43 Women with a History of Gestational Trophoblastic Disease

Abstract

Background: To analyze the clinical outcomes of in vitro fertilization (IVF)/intracytoplasmic sperm injection treatments in women with a history of gestational trophoblastic disease (GTD). Methods: This retrospective study included 43 patients with a history of GTD as the study group and 43 matched patients as the control group. The patients in the study group were divided into two groups according to the therapy received. Patients in Subgroup A (n = 32) underwent uterine curettage treatment only. Patients in Subgroup B (n = 11) underwent uterine curettage combined with chemotherapy. The characteristics of ovarian stimulation and outcomes of embryos and pregnancy were compared. Results: In the first cycle, there was a higher number of retrieved oocytes and normal fertilized oocytes in the control group than those in the study group (9.2 vs. 6.2 and 6.0 vs. 4.0, respectively; P 0.05). There was no difference in the outcomes between Subgroup A and Subgroup B. There was a significant difference in thickness of the endometrium between the control group and study group (10.9 mm vs. 9.2 mm, respectively; P Conclusions: Patients with a history of GTD can present with a similar normal fertilization rate and number of viable embryos. However, patients with a history of GTD may have a thinner endometrium and lower ongoing pregnancy rate. Hysteroscopy before frozen embryo transfer and usage of an IUD can improve the occurrence of IUA.