Abstract
Successful reproduction in mammals requires gamete development, fertilization, and early embryonic development. Defects in any of these processes can lead to infertility, recurrent miscarriages, and congenital defects. The clinical recognition of the genetic causes of female reproductive insufficiency using increasingly advanced genetic technologies poses a serious challenge for reproductive medicine in the 21 st century. Herein, current literature on genetic factors involved in reproductive losses was summarized. A literature search was conducted using Web of Science, MEDLINE, and PubMed databases for articles written in English on the genetic causes of women’s reproductive health disorders. Future implementation of whole-exome and -genome sequencing is expected to identify numerous genetic factors responsible for oocyte quality. Which will aid in increasing the likelihood of successful female reproductive function, improve the outcomes of assisted reproductive technologies, optimize treatment, and facilitate genetic diagnosis of patients.
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