The clinical features and prognostic factors of osteosarcoma in adult.

Abstract

Objective To study clinical features and outcomes of adult osteosareoma and evaluate prognostic factors for survival. Methods The clinical data of 30 over 40 years old of os-teosarcoma were retrospectively reviewed between March 2003 and March 2005, which included sex, age, tumor site, et al. Kaplan-Meier method was used to measure the overall survival rate. And log-rank univari-ate analysis was used to find prognostic factors related with survival rate. And Cox model multivariate analy-sis was used to find which prognostic factor was the independent one. Results All the were fol-lowed up at least 3 years, and 13 patient died with a median survival of 16months (range, 3-35 months) . Overall surviral rate was 56.7%. The tumors were at extremitities in 20 cases and axial bones in 10 cases. In X-ray film, 17 cases showed osteolytic lesions, 8 showed mixed, and 5 showed osteoblastic lesions. There were 22 cases with normal serum AKP levels, and 8 cases with higher levels of serum AKP. Overall surviral rate of 3 years was significantly related to patients age, tumor site, serum AKP level, Enneking surgical stage, surgical method and distant metastasis (Log-rank, P 0.05). Coulusion The clinical features of adult with osteosareoma was different from the young. There were more cases with tumor on axial bones in adult, and more cases with a normal serum AKP level, and osteolytic radiological finding. Surgical method played an important role in prognosis for survival in adult osteosarcoma patients. Key words: Adult; Osteosarcoma; Prognosis