Abstract

Objective To explore the prognostic factors of osteosarcoma.Methods Clinical data of 32 cases with osteosarcoma were retrospectively reviewed.Sex,age,course of disease,serum level of alkaline phosphatase (AKP),tumor size,tumor site,Enneking surgical stage,surgical method and distant metastasis were statistically analyzed.Results All the patients were followed up,and 12 patients died with a median survival of 6-52 (40.28 ± 5.58) months.Overall survival rate of 3 years was 62.5％ (20/32).Univariate analysis revealed that the prognosts of osteosarcoma was significantly related to tumor site,Enneking surgical stage,surgical method and distant metastasis.Multivariate analysis suggested that Enneking surgical stage,surgical method and distant metastasis were independent prognostic factors.Conclusions Enneking surgical stage,surgical method and distant metastasis are independent prognostic factors.Early diagnosis and the radical resection of tumor can improve the prognosis. Key words: Osteosarcoma; Prognosis; Multiple prognostic factors analysis

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