The clinical efficacy of concurrent radiochemotherapy for elderly patients with advanced cervical cancer and its influence on serum CA family and cognitive function

Abstract

Objective To evaluate the clinical efficacy of concurrent radiochemotherapy for elderly patients with advanced cervical cancer and its influence on serum CA family and cognitive function. Methods 106 elderly patients with advanced cervical cancer in our hospital between Oct. 2015 and Oct. 2017 were divided into observation group and control group by stratified randomization method. The observation group was treated by concurrent radiochemotherapy, while the control group was treated by normal radiotherapy. The clinical efficacy, serum levels of CA125, CA50, CA199, CA724, and cognitive function were compared between the two groups. Results After the treatment, the total effective rate in the observation group (86.79%) was higher than that in the control group (69.81%), with statistically significant difference (P<0.05). Serum levels of CA125, CA50, CA199, CA724 obviously reduced in the observation group compared with the control group, with statistically significant differences (P<0.05). The score of cognitive function obviously reduced in the control group, with statistically significant difference compared with the observation group (P<0.05). Conclusions Concurrent radiochemotherapy has significant clinical effect in the treatment of elderly patients with advanced cervical cancer, which can significantly reduce serum levels of CA125, CA50, CA199, CA724, avoid the aggravation of the cognitive dysfunction, worthy of clinical promotion. Key words: Concurrent radiochemotherapy; Advanced cervical cancer; Clinical efficacy; Serum CA; Cognitive function