The clinical effects of combined use of Sulodexide and valsartan on chronic glomerulonephritis

Abstract

Objectives To observe the clinical effects of combined use of Sulodexide and valsartan on chronic glomerulonephritis(CGN).Methods 97 cases of CGN patients in Mianyang Central Hospital were divided into two groups:group Ⅰ (drug combination:Sulodexide 500LSU · d-1 and valsartan 80mg · d-1),group Ⅱ(valsartan group:valsartan 80mg · d-1.Before and after 4 months of treatment,the detection result including 24-hour urinary protein excretion,Serum albumin,Plasma fibrinogen,prothrombin time,Activated partial thromboplastin time,Triglycerides,Total cholesterol,Serum creatinine,Urea nitrogen,Cystatin C and Blood pressure,were recorded and analyzed.Results To the contrast,in Serum albumin,prothrombin time,Activated partial thromboplastin time,Triglycerides,Total cholesterol,Serum creatinine,Urea nitrogen,Cystatin C and Blood pressure,there were no difference between the before and after 4 months of treatment(P ＞ 0.05).24-hour urinary protein excretion,Plasma fibrinogen and Cystatin C were significantly lower after 4 months of treatment than that before treatment (P ＜ 0.05).Compared with the valsartan group,24-hour urinary protein excretion,Plasma fibrinogen and Cystatin C were significantly lower in drug combination group(P ＜ 0.01).Conclusions Compared with monotherapy,combination of Sulodexide and valsartan can provides better efficacy,which also provides a new direction for the treatment of chronic glomerulonephritis. Key words: Glomerulonephritis; Chronic Disease