The clinical effect of Tongfu-Xiefei decoction for the patients with AECOPD with phlegm-heat syndrome

Abstract

Objective To observe the clinical effect of Tongfu-Xiefei decoction for the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with phlegm-heat syndrome. Methods A total of 78 AECOPD patients were selected from June 2015 to December 2016 in the respiratory department of our hospital, and the patients were randomly divided into two groups according to the random number table method, 39 patients in each group. The control group was treated with convertional western medicine and placebo decoction. Treatment group was treated with convertional western medicine and true decoction. Both groups were treated for 2 weeks and fellowed up for 4 weeks. The symptoms score, SGRQ scores, blood gas analysis were observed and analyzed. The clinical curative effect and adverse evevts were observed. Results After treatment, the symptom cough (2.34 ± 1.11 vs. 2.67±1.05, t=2.277), expectoration (1.91 ± 1.41 vs. 2.35 ± 1.83, t=2.106), asthmoid (1.73 ± 1.15 vs. 2.04 ± 1.53, t=2.214) scores in the treatment group were significantly lower than the control group (P<0.05). The SGRQ scores (42.47 ± 17.24 vs. 59.95 ± 17.58, t=2.112) in the treatment group was significantly lower than the control group (P<0.05). The total effective rate in the treatment group was 91.9% (34/37) and 84.4% in the control group (27/32). The difference between the 2 groups was statistically significant (χ2=4.578, P=0.040). Conclusions The Tongfu-Xiefei decoction can effectively alleviate the symptoms and signs, improve the blood gas analysis index, and the long-term curative effect for AECOPD patients with phlegm-heat syndrome. Key words: Pulmonary disease, chronic obstructive; Tongfu-Xiefei decoction; Syndrome differentiation classification; Clinical study