Abstract
Dexmedetomidine exerts sedative, analgesic and anti-sympathetic effects mainly through activating α2-adrenergic receptors in the presynaptic and posterior membranes.It has little influence on respiratory system as well as hematological dynamics.In addition, it can be administered by nasal instillation with fast effect, minor trauma and proper duration of action.In recent years, it has been gradually used in neonatal anesthesia assistance, sedation and analgesia of mechanical ventilation, auxiliary examination, etc.This article reviews the progress in clinical application of dexmedetomidine in neonates. Key words: Dexmedetomidine; Sedation; Analgesia; Newborn
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