Abstract
1. The plasma clearance and urinary excretion of 3H-FA were observed in normal subjects and patients with hematological and hepatic diseases.2. 3H-FA in a dose of 20μg per kg of body weight was intravenously injected. The plasma clearance was observed for 6 hours and the urinary excretion for 12 hours.3. In 6 control subjects, 3H-FA in the plasma was 13.06, 7.05, 4.51, 3.08, 2.14, 1.59 and 0.41 per cent of the dose per liter of plasma 5, 15, 30, 60, 90, 120 minutes and 6 hours following the injection, respectively. The urinary excretion of 3H-FA in 12 hours ranged from 16.8 to 31.3 per cent, with a mean of 25.5 per cent.4. An abnormally rapid clearance and low urinary excretion of 3H-FA were observed in all the cases of pernicious anemia and in almost all the cases of aplastic anemia.5. In some cases of acute leukemia abnormally rapid clearance and low urinary excretion of 3H-FA were observed, while in patients with chronic leukemia all cases showed an abnormally rapid clearance and low urinary excretion.6. In patients with acute hepatitis, the results varied from case to case. In some cases of liver cirrhosis and chronic hepatitis, abnormally rapid clearance and low urinary excretion of 3H-FA were observed.7. Furthermore, organ distribution and urinary excretion of 3H-FA were observed in the rats after intravenous administration of 50 or 200μg of 3H-FA per kg of body weight.8. In the rats pretreated with CCl4, high urinary excretion and low hepatic uptake of 3H-FA were observed in the early stadium, while low urinary excretion and high hepatic uptake were observed in the late stadium. These results were in good agreement with those of patients with acute hepatitis.9. In the rats pretreated with Amethopterin, disturbed FA metabolism was proved by low hepatic and renal uptakes, and high urinary excretion of 3H-FA.10. The causes of abnormal plasma clearance and urinary excretion of 3H-FA in man and abnormal organ distribution in rats were discussed in each case.
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