Abstract
In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined. The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders. Very recently, beneficial effects of naringenin have been demonstrated in old rats. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated. For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. These results suggested that naringenin has antiaging effects on myocardial cells.
Highlights
Naringenin (Nar), a bitter flavanone mainly present in citrus fruits and tomatoes, is a common component of the human diet
Nar stimulates the mitochondrial calcium-dependent potassium channel, which causes an influx of potassium ions, a mild depolarization, and a decrease in the mitochondrial matrix calcium uptake, all of which contribute to stabilizing the mitochondria during cellular damage [3, 4]
Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, together, the data have prompted us to investigate the effects of Nar in a cellular model of aged myocardial cells
Summary
Naringenin (Nar), a bitter flavanone mainly present in citrus fruits and tomatoes, is a common component of the human diet. This compound has received considerable attention for its health-promoting and disease-preventing effects, and interest in its pharmaceutical and nutritional effects has increased [1]. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, together, the data have prompted us to investigate the effects of Nar in a cellular model of aged myocardial cells. To the best of our knowledge, the effect of Nar in cardiac cell senescence has not yet been studied. The results demonstrated that Nar exerts effective antiaging properties in myocardial cells
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