Abstract
Sheep anterior lens capsule was isolated, and its amino acid and carbohydrate composition determined. Anterior lens capsule appears to be a complex polymer of a collagen-like glycoprotein in association with noncollagen-like glycoproteins. In this respect it resembles other basement membranes. It contains large amounts of glycine, hydroxyproline, and hydroxylysine (28, 12, and 4% of the amino acid residues, respectively). The total carbohydrate content of sheep anterior lens capsule is about 11.0 by weight, composed of glucose (4.2%), galactose (5.2%), mannose (0.5%), fucose (0.4%), glucosamine (0.46%), galactosamine (0.12%), and sialic acid (0.12%). The collagen component from sheep anterior lens capsule was isolated by limited digestion with pronase or pepsin at low temperatures. The amino acid and carbohydrate composition of the collagen from lens capsule resembles that of collagen obtained from glomerular and Descemet's membranes. In terms of residues per 1000 residues it contains glycine 338, proline 65, hydroxyproline 154, hydroxylysine 51, and half-cystine 5. It contains about 14% hexose composed of equimolar amounts of glucose and galactose. The collagen obtained after digestion with pepsin has an intrinsic viscosity of 13.1 dl/g and a molecular weight of 284,000. Anterior lens capsule contains a higher proportion of this collagen component compared to Descemet's membrane or glomerular basement membrane.
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