The Chemical Composition and Anti-mycobacterial Activities of Trachyspermum copticum and Pelargonium graveolens Essential Oils.

Mohammad M. Feizabadi,Gholamreza Hamzelou,Jalil Kardan-Yamchi,Mohaddese Mahboubi,Hossein Kazemian

doi:10.2174/1574891x14666191028113321

Abstract

Background Microbial resistance to antibiotics and their adverse effects related to these antibiotics are a matter of global public health in the 21th century. The emergence of drug-resistant strains, has gained the interest of the scientists to discover new antimicrobial agents from the essential oil of medicinal plants.Methods Anti-mycobacterial effects of Trachyspermum copticum and Pelargonium gra-veolens essential oils were determined against multi-drug resistant clinical strains of Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium fortuitum and standard strain of Mycobacterium tuberculosis H37Rv by a Broth micro-dilution method. Pelargonium graveolens plant named Narmada was discovered by Kulkarni R.N et al. (Patent ID, USPP12425P2) and a formulation comprising thymol obtained from Trachyspermum is useful in the treatment of drug-resistant bacterial infections (Patent ID, US6824795B2). The chemical composition of hydro-distilled essential oils was determined by GC and GC-MS.Results Minimum Inhibitory Concentration (MIC) values for T. copticum essential oil against tested isolates were ranged from 19.5 µg/mL to 78 µg/mL. The least minimum inhibitory concentration of P. graveolens extract against M. Kansasii and MDR-TB was 78 µg/ml.Conclusion The results of the present research introduced T. copticum and P. graveolens essential oils as a remarkable natural anti-mycobacterial agent, but more pharmacological studies are required to evaluate their efficacy in animal models.

Highlights

Due to the emergence of drug-resistant microorganisms [1, 2], scientists have focused on natural resources, such as plants, animals, and microorganisms, in order to discover newer antimicrobi al Antimycobacterial Activities of T.trachyspermum & P.graveolens is useful in the treatment of drug-resistant bacterial infections (Patent ID, US6824795B2) [8].Trachyspermum copticum, a member of the Apiaceae family is native to the Middle East
Minimum Inhibitory Concentration (MIC) values for T. copticum essential oil against tested isolates were ranged from 19.5 g/mL to 78 g/mL
Analysis of the chemical composition of Trachyspermum copticum essential oil showed the presence of 26 compounds that comprised 99.34% of total oil compositions

Summary

Introduction

Due to the emergence of drug-resistant microorganisms [1, 2], scientists have focused on natural resources, such as plants, animals, and microorganisms, in order to discover newer antimicrobi al Antimycobacterial Activities of T.trachyspermum & P.graveolens is useful in the treatment of drug-resistant bacterial infections (Patent ID, US6824795B2) [8].Trachyspermum copticum, a member of the Apiaceae family is native to the Middle East. Due to the emergence of drug-resistant microorganisms [1, 2], scientists have focused on natural resources, such as plants, animals, and microorganisms, in order to discover newer antimicrobi al Antimycobacterial Activities of T.trachyspermum & P.graveolens is useful in the treatment of drug-resistant bacterial infections (Patent ID, US6824795B2) [8]. The seeds and roots of Trachyspermum copticum have been used traditionally due to its diuretic and aphrodisiac activities [9]. Rather than the antimicrobial activity [14] of T. copticum essential oil, its antihypertensive, antispasmodic and broncho-dilating and hepatoprotective effects [15], diuretic activity [16], antiinflammatory [17], antitussive [18] and gastroprotective effects have been demonstrated [19]. The emergence of drug-resistant strains, has gained the interest of the scientists to discover new antimicrobial agents from the essential oil of medicinal plants.

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Results

Discussion

Conclusion