Abstract
Skin-sensitizing antibody (SSA) to ragweed was induced in four nonatopic dogs following four weekly injections of ragweed emulsion. The characteristics of the SSA are similar to those occurring spontaneously in man and dog. A challenge of one of the dogs by insufflation and intravenous administration of ragweed pollen extract failed to produce any systemic symptoms. This suggested the presence of a high level of blocking antibody. One of the dogs developed ulceration and granuloma formation at each site of injection. Biopsies were taken during the stage of active ulceration and after complete healing.
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