Abstract
Objective To explore the characteristics of visual P300 event-related potentials (ERP) in children with mental retardation and evaluate the correlations between visual P300 in event-related potentials and intelligent quotient. Methods Thirty children with mental retardation were selected as the test group who were inpatients or saw a doctor in the Department of Rehabilitation of Hunan Children Hospital. At the same time, thirty normal children were selected as the control group who saw a doctor in the Department of Child Healthcare of Hunan Children Hospital. Two groups had no statistically significant difference in sex and age (P>0.05) and were comparable. All children were administered with the Wechsler intelligence test in the Department of Child Healthcare and the visual event-related potential test in the Department of Rehabilitation. The results of the visual P300 latency and amplitude were analyzed. Another, the relevance between intelligent quotient (IQ) and P300 latency and amplitude were also compared by statistics. Results Compared to the control group, the visual P300 latency in children with mental retardation (MR) was apparently longer and the amplitude decreased significantly in children with MR, with a statistically significant difference between two groups(P<0.05). P300 latency in MR expected negative correlation with intelligent quotient and the amplitude in MR expected no correlation with intelligent quotient. Conclusions P300 latency and amplitude of ERP could objectively reflect cognitive function in children with MR, could be regarded as one of the objective measurement in the evaluation of cognitive function in children with MR. It can be used as an objective electrophysiological index for assisting in the diagnosis of mental retardation of children in clinic. Key words: Mental retardation/PP; Event-related potentials, P300; Intelligence; Evoked potentials, visual
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