The characteristic feature of glucocorticoids after local application with reference to leucocyte migration and protein exudation

Abstract

The carboxymethyl cellulose (CMC) pouch method which was developed to measure leucocyte migration and protein exudation simultaneously in acute experimental inflammation was used for the quantitative analysis of the characteristic feature of glucocorticoids after local application. The order of inhibitory potency of the steroidal anti-inflammatory agents on leucocyte migration was in good agreement with data obtained in other laboratories based on different biological responses. The glucocorticoids did not show any potent inhibitory effect on the exudation of protein even at higher dose levels in which 70–80% of leucocyte migration was inhibited. This may be because of the short treatment time. From the above results, it is suggested that the anti-inflammatory action of glucocorticoids after local application is much more potent in inhibiting the migration of leucocyte as compared with the inhibitory action on vascular permeability. Anti-inflammatory drugs Leucocyte migration CMC pouch method Protein exudation