Abstract
In the 1990's, increasing use of antenatal steroid and routine surfactant therapy has enabled us to wean infants off of ventilatory support at much earlier postnatal ages. Even infants with 1 Kg were: 13(13) in Period A, and 13(15) days in Period B. In 1 Kg infants were 13(25) in Period A and 19(27) days in Period B. Other data are in the Table. Summary and Conclusions In <1 Kg infants, there was a slight reduction in the overall duration of assisted ventilation in Period B. However, neither the overall duration of O2 requirement nor the rate of BPD (as defined above) changed significantly over the time course. It appears that the impact of antenatal steroid and surfactant is far greater on the early course of preterm infant's lung disease rather than on the course later during the first month.
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