The changes of the serum ferritin,fibrinogen and D-dimer levels in patients with small vessel disease and its significance

Abstract

Objective To explore the correlation of serum ferritin （SF）,fibrinogen（FIB） and D-dimer levels in patients with small vessel disease（SVD）.Methods 359 patients with SVD were selected,including 186 patients with lacunar infarction （ LI） and 173 patients with leukoaraiosis （ LA） .176 healthy controls were enrolled in this study as control group.The SF,FIB and D-dimer concentrations were measured by radioimmunoassay method and Clauss method respectively .Results The serum levels of SF , FIB and D-dimer in SVD patients were significantly higher than those in the controls [（171.82 ±156.28）μg/L vs （100.37 ±70.11）μg/L,（3.27 ±0.93） g/L vs （2.97 ± 0.88）g/L,（1.10 ±1.06）mg/L vs （0.83 ±0.55）mg/L]（all P〈0.05）.Compared with LI subgroup,the levels of SF,FIB and D-dimer were higher in LA subgroup [（185.22 ±108.55）μg/L vs （159.36 ±89.69）μg/L,（3.32 ± 0.86）g/L vs （3.23 ±0.99）g/L,（1.29 ±1.17）mg/L vs （1.03 ±0.80）mg/L],but the differences were not signifi-cant（all P〈0.05）.Multivariate regression analysis revealed that by comparison to the reference quartile ,the odds ra-tio （95%CI） for SVD patients in the higher quartile （SF>151.16μg/L,D-Dimer>1.02 mg/L） were 3.444（95%CI=2.097-5.158,P〈0.001） and 1.767（95%CI=1.114-2.803,P=0.016）,respectively after multivariable ad-justment.Conclusion The increased levels of SF ,FIB and D-dimer are closely related with SVD .FIB and D-dimer might come to be attractive approaches to prevent the progress of SVD . Key words: Small vessel disease; Ferritins; Fibrinogen; D-dimer