The changes of serum nerve growth factor and interleukin-15 in children with mycoplasma pneumoniae pneumonia and its clinical significance

Abstract

Objective To investigate the changes of serum nerve growth factor(NGF) and interleukin(IL)-15 levels in children with mycoplasma pneumoniae pneumonia(MPP) and its clinical significance. Methods Using the antibody sandwich ELISA method to measure the serum NGF and IL-15 levels in 65 cases of MPP (MPP group, which contains two groups: the severe group contains 25 patients and the mild group contains 40 patients) and 50 cases of healthy children (normal control group). Results The serum NGF, IL-15 levels in the acute phase of MPP group were (157.62±33.45) pg/ml and (242.51±60.04) pg/ml, and in the recovery period were (99.58±21.29) pg/ml and (145.90±50.25) pg/ml, they were all significantly higher than the normal control group [(29.86±11.74) pg/ml and (108.86±21.14) pg/ml, P 0.05). Conclusion The serum levels of NGF, IL-15 in the mycoplasma pneumoniae infection patients are significantly increased, and they are all decreased as the disease mitigation.It is prompted that NGF and IL-15 participate in the pathogenesis of infection by mycoplasma pneumoniae. Key words: Mycoplasma pneumoniae pneumonia; Nerve growth factor; Interleukin-15