The level changes and clinical value of serum nerve growth factor and interleukin-15 in children with mycoplasma pneumoniae pneumonia

Abstract

Objective To investigate the level changes and clinical value of serum nerve growth factor(NGF)and interleukin-15(IL-15)in children with mycoplasma pneumoniae pneumonia. Methods A retrospective study was performed on 90 patients with mycoplasma pneumoniae pneumonia(MPP)who were admitted from July 2014 to April 2015.At the same time, another 90 medical healthy children were selected as the control group in the same period.The serum NGF, IL-15 level changes.The serum NGF and IL-15 level changes in different onset age children with MPP and healthy children, and in critically ill children and children with mild acute phase were compared. Results Acute onset of nerve growth factor in serum and recovery period, the NGF and IL-15 were higher than those in the control group, and the difference was statistically significant(P<0.05); nerve growth factor in serum of children with acute exacerbation, NGF and IL-15 level were significantly higher than those of children in the recovery period, and the difference was statistically significant(P<0.05); in group of children with severe acute exacerbation, serum NGF and IL-15 level were significantly higher than those in children with mild group, and the difference was statistically significant(P<0.05); in group of children with severe recovery of nerve growth factor, the serum NGF, IL-15 levels were significantly higher than those in children with mild group, and the difference was statistically significant(P<0.05). Conclusion Serum NGF and IL-15 are checking sensitive index in MPP children, which can be used to evaluate the disease severity in MPP children, it is worth clinical promotion. Key words: Pneumonia; Mycoplasma pneumonia; Interleukin-15; Nerve growth factor