Abstract
Objective:To evaluate the changes of adipocytokines after surgery in OSAHS patients with insulin resistance.Method:Eighty-four OSAHS patients were enrolled in this study and divided into two group based on insulin resistance: IR group(n=52) and non-IR group(n=32). All patients received UPPP surgery. The levels of chemerin,visfatin and obestatin were measured before and one week after surgery.Result:Before surgery,the levels of chemerin,visfatin and HOMA-IR in IR group were higher than those in non-IR group,while level of obestatin was lower than those in non-IR group. One week after surgery,the level of obestatin in IR group was lower than those in non-IR group. The levels of chemerin,visfatin and HOMA-IR were decreased while obestatin increased after surgery. Correlation analysis showed that UPPP surgery was negatively related with △chemerin（r=-0.685，P<0.05）and △HOMA-IR（r=-0.622，P<0.05）.△HOMA-IR was positively associated with △chemerin（r=0.634，P<0.05）.Conclusion:The levels of chemerin,visfatin and obestatin are significantly improved after UPPP surgery. Level of chemerin seems to have a close relationship with IR.
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Schedule a callMore From: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
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