Abstract
Objective: Over-expression of cyclin-dependent kinase 1 (Cdk1) is associated with poor survival in high-grade serous ovarian cancer (OC). Cdk1 is a critical regulator of cell cycle progression, specifically G2 and S phase transit. In addition, Cdk1 is required for the efficient recruitment of BRCA1 to sites of DNA damage. We evaluated the in vitro and in vivo effects of Cdk1 inhibition byRO3306 in serous OC.
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