Abstract
Close examination of how the CD4 and CD8 genes are regulated during T lymphocyte development, not only in the thymus but also in secondary lymphoid organs, has provided with valuable insight into mechanisms of lineage specification. Studies in this area promise to uncover how helper versus cytotoxic T cells differentiate, and, possibly, even how effector T cells give rise to subsets of long-lived memory T cells with specialized activation properties. In a more general sense, examination of these loci has provided a unique opportunity to study epigenetic regulation in vertebrate development. The CD4 locus remains the only vertebrate gene currently shown to undergo developmentally regulated epigenetic silencing, and as such, it presents an ideal system for analyzing how heterochromatin is established during developmental processes in higher eukaryotes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
