Abstract
Junctophilin 3 (JPH3) and junctophilin 4 (JPH4) are both expressed in neurons, where they form ER-PM junctions, regions in which the endoplasmic reticulum comes into close proximity with the plasma membrane. By allowing cross-communication between voltage- and ligand-gated channels in the PM and Ca2+-releasing channels in the ER, junctophilin-induced ER-PM junctions are critical for neuronal function. We previously showed that JPH3 and JPH4 recruited high-voltage activated Ca2+ channels into ER-PM junctions when transfected in tsA201 cells.
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