Abstract

Schizophrenia is one of the ten most disabling diseases in the world, mainly manifested by different syndromes such as incoordination of mental activity and behavior. Its pathogenesis and influencing factors are still unclear. Schizophrenia occurs mainly in patients who are in adolescence or just entering adulthood. Men are more likely to get the disease than women, and the disease course is longer, and is prone to recurring, exacerbating, or worsening. Research shows that the main causes of schizophrenia can be divided into psychosocial and biological factors. Among the social psychological factors, such as abnormal personality, it may lead to contradictory psychological phenomena; among family factors, the economic level is low, the family relationship is bad, and major psychological shocks are encountered; or social factors such as religious beliefs may lead to schizophrenia disease. Among the biological factors, schizophrenia can be caused due to the poor condition of genes. Genetic factors are the main pathogenic factors of schizophrenia. ErbB4, Dystrobrevin binding protein 1 (DTNBP1), Neuregulin-1 (NRG1), neurotransmitter dopamine and catechol-O-methyltransferase (COMT) genes are biological factors that lead to schizophrenia. This article mainly discusses the etiology of adolescent schizophrenia. Risk factors for schizophrenia are abnormal personality and adverse genetic factors. By far the most important causative factor is due to biological genetic factors. In new scientific research, CRISPR technology may be able to cure genotype schizophrenia by modifying genes. However, maintaining a healthy mind or seeking medical attention when a problem is discovered can prevent mental illness in time.

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