Abstract
A highly efficient Cu(II)-catalyzed enantioselective inverse-electron-demand aza-Diels-Alder reaction of in situ formed azoalkenes with enol ethers is reported. This methodology provides a facile entry to biologically important and enantioenriched tetrahydropyridazine derivatives in generally good yield (up to 95% yield) with good to excellent enantioselectivity (up to 94% ee).
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