Catalytic asymmetric aldol reaction of the silyl enol ether of acetic acid thioester with aldehydes using chiral tin(II) Lewis acid

Abstract

Catalytic asymmetric aldol reaction of the silyl enol ether derived from S-ethyl ethanethioate with achiral aldehydes is carried out by using chiral diamine-coordinated tin(II) triflate to afford the corresponding aldol-type adducts, α-unsubstituted β-hydroxy thioesters, in good yields with high ees.