Abstract
BackgroundAttention to additional factors affecting the success of assisted reproduction techniques (ARTs) is very important and with appropriate interventions in some of these factors, success rate can be as high as improve a lot. There is a lot of evidence that lifestyle factors can influence on ARTs outcomes. Current knowledge of the effect of combined effect of several lifestyle factors on the outcomes of ARTs is low and contradictory. The importance of the causality of this phenomenon is felt by the pandemic of inappropriate lifestyle as well as the dramatic increase in infertility in the world. The aim of this cohort study is to scrutinize the casual effect of a specific range of contemporary lifestyle factors on ARTs outcomes.MethodsA prospective cohort study will be conducted in Royan institute, Tehran, Iran. Each infertile couple will be monitored from the first visit to the end of treatment cycle. The data will be collected electronically and include the following: detailed interview about lifestyle and socioeconomic status, past medical history, general physical examination, assessment of menstrual and ovulatory status, assessment of tuboperitoneal, assessment of uterine, assessment of cervix, urogenital examination, semen analysis, anti-sperm antibodies, biochemical analysis, sperm-cervical mucus contact test, in vitro cervical mucus penetration test and sperm functional assays. To estimate the casual effect of lifestyle variables on clinical pregnancy and live birth, the obtained propensity score (PS) from generalized boosted models (GBM) will be matched between couple with and without live birth.DiscussionThis is the first study to prospectively obtain detailed information on causes of ARTs success. Determining the casual effect of lifestyle variables on ARTs success will be important to inform strategies most likely to increase the success rates in ARTs.
Highlights
Attention to additional factors affecting the success of assisted reproduction techniques (ARTs) is very important and with appropriate interventions in some of these factors, success rate can be as high as improve a lot
Based on a systematic analysis of 277 demographic and reproductive health surveys, in 2010, among women 20 to 44 years old who were exposed to the risk of pregnancy, 1.9% were unable to achieve a live birth
These techniques have led to an increase infertility success significantly, attention to additional factors affecting the success of ARTs is very important and with appropriate interventions in some of these factors, success rate can be as high as improve a lot [7]
Summary
Attention to additional factors affecting the success of assisted reproduction techniques (ARTs) is very important and with appropriate interventions in some of these factors, success rate can be as high as improve a lot. The ultimate goal for treating infertile couple with ARTs is to maximize the number of patients delivering living child These techniques have led to an increase infertility success significantly, attention to additional factors affecting the success of ARTs is very important and with appropriate interventions in some of these factors, success rate can be as high as improve a lot [7]. The importance of the causality of this phenomenon is felt by the pandemic of inappropriate lifestyle as well as the dramatic increase in infertility in the world The aim of this cohort study is to scrutinize the impact of a specific range of contemporary lifestyle factors on ARTs outcomes. These factors include tobacco usage, drugs, weight, physical activity, alcohol drinking and caffeine consumption
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